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Observe Carefully (one)pentobarbital will minimize the level or effect of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the level or outcome of flurbiprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unfamiliar.pentobarbital will lessen the level or effect of